Researchers at Cornell University's College of Agriculture and Life Sciences have developed a new framework called NetFlow3D to analyze cancer-driving genetic mutations. The study, published on January 24 in Nature Communications, applies the framework to 33 different cancer types. Researchers used the three-dimensional structures of all human proteins and every known protein-protein interaction to determine how specific mutations may drive cancer.

The team used 3D clustering techniques within protein structures to distinguish mutations that contribute to cancer from those that do not. NetFlow3D is the first framework to incorporate the complete 3D structures of all known human proteins along with the full network of protein-protein interactions.

The research builds on decades of work by governmental, academic, and industry scientists. The genetic and molecular mapping for the 33 cancer types was provided by The Cancer Genome Atlas Program, an initiative of the U.S. National Institutes of Health. The use of 3D protein models, which began with Cambridge University researchers in the 1950s, has played a key role in advancing the study of protein structures and their role in disease.

Source: Cornell University

Source Type: College

Source Location: Ithaca

Ithaca, NY

https://www.facebook.com/709174307912162/posts/1043582797804643

CNN Ranks Appalachian Trail as Top Hiking Route

CNN ranks the Appalachian Trail's Shenandoah section among the world’s best hikes.

Stop-Work Order Halts Cornell Space Simulator Project

Cornell’s halted spacecraft simulator aimed to advance space technology testing.

Cornell's CJ Kirst Wins Prestigious Tewaaraton Award

Cornell’s CJ Kirst wins Tewaaraton Award as nation’s top lacrosse attacker.

Live Music Tonight at Six Mile Creek Vineyard

Michael Ciccone and Co. perform live at Six Mile Creek Vineyard tonight.

Cornell Research Advances Global Bird Flu Info

Cornell researchers distribute up-to-date, reliable bird flu information both locally and globally.

Cornell Reunion Festival Returns to Ithaca Next Week

Cornell Reunion in Ithaca June 5-8 welcomes alumni and community members.

Cornell Celebrates Historic Lacrosse Championship Win

Cornell celebrates 2025 NCAA Championship men's lacrosse title, first in 50 years.

Cornell Chef Serves Gourmet, Dreams of Restaurant

Cornell student chef crafts global gourmet meals, building career before restaurant dream.

Corn Belt Acts as Barrier for Migratory Songbirds

Migratory birds adjust flight over the Corn Belt like natural barriers.

Cornell Lacrosse Ends 48-Year Title Drought

Cornell men’s lacrosse wins its first national title in 48 years.