Cornell University researchers have developed a new biosensor technology that maps where and how kinases – enzymes that control many cellular processes – turn on and off inside living cells. The technique, called ProKAS (Proteomic Kinase Activity Sensors), provides detailed spatial resolution of kinase activity by using mass spectrometry.

The study, published on November 13 in Nature Communications, was led by Professor Marcus Smolka from Cornell’s College of Agriculture and Life Sciences and the Weill Institute for Cell and Molecular Biology. Researchers believe the ability to track kinase activity in such detail will help scientists better understand cellular processes like growth and DNA repair, as well as how cells respond to chemotherapy and diseases including cancer.

The development of ProKAS marks a significant advancement over previous microscopy-based techniques, offering a novel approach to studying the more than 500 kinases in human cells. This new tool may lead to improved insights into cellular signaling and more effective therapies in the future.

Further details about the biosensor technology can be found on Cornell University’s website.

Source: Cornell University

Source Type: College

Source Location: Ithaca

Ithaca, NY

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